ELEMENTAL PROFILING

ICP-MS Elemental Analysis

Elemental Profiling — Multi-Element Quantification by ICP-MS

Elements participate in key biological processes such as enzyme active centers, signal transduction and redox balance. Deficiencies of nutritional elements (Ca, Mg, Zn, Se) and exposure to heavy metals (Hg, Pb, Cd, As) are closely linked to metabolic dysregulation and chronic disease. Based on inductively coupled plasma mass spectrometry (ICP-MS), this service covers 43 elements in a single run and can report by category—nutritional minerals / micronutrients / toxic elements—for nutrition assessment, heavy-metal exposure and toxicity studies, and environment-and-health cohorts.

43
detectable elements
DETECTABLE ELEMENTS
ICP-MS
ICP-MS platform
PLATFORM
28
categorized report indicators (incl. Cu/Zn)
REPORT INDICATORS

Targeted List

Targeted Compound List
Targeted List (partial)
NO.ElementSymbol
1钙Ca
2钾K
3镁Mg
4钠Na
5磷P
6铬Cr
7锰Mn
8钴Co
9钼Mo
10铜Cu
11硒Se
12铁Fe
13锌Zn
14硼B
15硫S
16锂Li
17钒V
18锶Sr
19铝Al
20铅Pb
21砷As
22汞Hg
Full list available on request — contact our team.

Technical Specifications

TECHNICAL SPECIFICATIONS
PlatformInductively coupled plasma mass spectrometry (ICP-MS)
Acquisition modeCollision cell (He-KED) removes polyatomic interferences; simultaneous multi-element acquisition
Quantification UnitStandard-curve quantification, μg/L or μg/g
QCCertified reference materials + in-queue QCs to monitor recovery and batch stability

Sample Requirements

SAMPLE REQUIREMENTS
Whole blood / serum
200 μL
Urine
1 mL
Tissue
50 mg
Hair / nails
50 mg
Water samples
5 mL
Feed / matrices
200 mg
Replicates: cell / microbial samples ≥6 replicates per group; animal samples ≥10 per group; clinical samples ≥50 per group with strictly controlled inclusion criteria. Sampling site, timing and handling must be consistent between experimental and control groups.
Submission notes: applicable to whole blood / serum, urine, tissue, hair / nails, water and feed / matrix samples; solid samples are microwave-digested (nitric-acid system) before analysis; recommended amounts are per single assay—submit 2–3× the recommended amount; keep sampling sites consistent across groups for tissue; ship refrigerated.

Workflow

WORKFLOW
1
Consultation
Study goals / panel selection
2
Proposal & Quote
Targets / timeline / agreement
3
Sample Intake
Cold chain / pre-check / labeling
4
Experiment
Acquisition / QC
5
Delivery
Quantification + interpretation + raw data
Deliverables: quantitative results table for 43 elements (content + units) · summary by nutritional-mineral / micronutrient / toxic-element categories · group-wise T-test and fold-change analysis · hierarchical clustering and PCA modeling · full analysis report and raw data.

References

REFERENCES
[1] MOHAMMED NAWI A, CHIN S F, JAMAL R. Simultaneous analysis of 25 trace elements in micro volume of human serum by inductively coupled plasma mass spectrometry (ICP-MS)[J]. Practical Laboratory Medicine, 2020, 18: e00142.
[2] ZHANG G, ZHANG F, LIU W, et al. A simple, rapid method for simultaneous determination of multiple elements in serum by using an ICP-MS equipped with collision cell[J]. BMC Chemistry, 2023, 17(1): 34.

Applications

APPLICATIONS
Trace-element nutrition assessmentHeavy-metal contamination testingMineral-element metabolism researchElemental analysis of food & environmental samplesElemental profiling of biological samples

FAQ

FAQ
How long does a ICP-MS Elemental Analysis project take?
Mature targeted panels typically take 1-3 weeks; untargeted projects take 2-4 weeks (counted from sample receipt and QC approval). The exact timeline is confirmed in writing before project start, and progress is trackable on the OmicsHub cloud platform.
What if my sample amount is below the recommendation?
Please do not dilute your samples. Low-input samples can often be accommodated by adjusting the preparation workflow — tell us the actual amount and our technical team will assess feasibility and note adjustments in the study plan.
Can I add targets to an existing panel?
Yes. Mature panels support on-demand additions; novel analytes outside the list can be implemented through custom method development (requires standards and extra validation time) — see our Custom Targeted Metabolomics service.
What samples do you need for ICP-MS Elemental Analysis?
Serum/plasma ≥100 μL (fasting, no haemolysis), tissue ≥50 mg (snap-frozen), cells ≥1×10⁶ (medium washed off), urine ≥200 μL. Keep fasting time consistent, aliquot into single-use volumes and avoid freeze–thaw. Full guidance: Technical Resources → Sample Guide.

Delivery timing: sample shipping, customs declaration and similar steps may extend turnaround; actual project timelines prevail.

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