---
title: "Organic Acids Panel"
lang: en
url: https://www.gereallife.com/en/services/organic-acids.html
canonical: https://www.gereallife.com/en/services/organic-acids.html
entity: Shanghai Gereallife Biotech Co., Ltd
updated: 2026-11-02
---
ORGANIC ACID PROFILING 
 

# Organic Acids Panel

 

Organic Acid Profiling — Absolute Quantification

 

Organic acids include TCA-cycle intermediates, short-chain dicarboxylic acids, and characteristic products of branched-chain-amino-acid and fatty-acid oxidation; their abnormal accumulation is a classic biochemical hallmark of inherited metabolic diseases (organic acidemias) and mitochondrial dysfunction. This service absolutely quantifies 60+ organic acids for energy-metabolism, mitochondrial-disease and inherited-metabolic-disease screening research.

 
 
 60+ target organic acids TARGET COMPOUNDS 3 sources: TCA / amino acids / FA oxidation METABOLIC ORIGINS MRM Isotope-IS Absolute Quantification ABSOLUTE QUANTIFICATION 

## Targeted List & Analysis Examples

 Targeted List & Analysis Examples Targeted List (partial) 
 

| NO. | Chinese Name | Abbr. | English Name | CAS No. |
| --- | --- | --- | --- | --- |
| 1 | 己二酸 | R1 | Adipate | 124-04-9 |
| 2 | 辛二酸 | R2 | Suberate | 505-48-6 |
| 3 | 乙基丙二酸 | R3 | Ethylmalonate | 601-75-2 |
| 4 | 丙酮酸 | R4 | Pyruvate | 127-17-3 |
| 5 | 乳酸 | R5 | Lactate | 79-33-4 |
| 6 | β-羟基丁酸 | R6 | BHBA | 300-85-6 |
| 7 | 柠檬酸 | R7 | Citrate | 77-92-9 |
| 8 | 顺式乌头酸 | R8 | Cis-aconitate | 585-84-2 |
| 9 | 异柠檬酸 | R9 | Isocitrate | 1637-73-6 |
| 10 | α-酮戊二酸 | R10 | AKG | 328-50-7 |
| 11 | 琥珀酸 | R11 | Succinate | 110-15-6 |
| 12 | 富马酸 | R12 | Fumarate | 110-17-8 |

 Full list available on request — contact our team. 
 

## Technical Specifications

 TECHNICAL SPECIFICATIONS 

| Platform | UHPLC coupled with triple-quadrupole MS (UHPLC-MS/MS) |
| --- | --- |
| Ion Mode | Positive/negative ion switching acquisition |
| Quantification Unit | Standard-curve absolute quantification, ng/mL or ng/g |
| QC | Pooled QC samples inserted across the batch to monitor signal drift and stability |

 
 

## Sample Requirements

 SAMPLE REQUIREMENTS Serum / Plasma 50 μL Tissue 30 mg Cells 1–5 × 10⁶ cells Feces / Gut Content 100 mg fresh / 20 mg lyophilized Urine 50 μL Exosomes 50 μL Replicates: cell / microbial samples ≥6 replicates per group; animal samples ≥10 per group; clinical samples ≥50 per group with strictly controlled inclusion criteria. Sampling site, timing and handling must be consistent between experimental and control groups. Shipping notes: applicable to serum/plasma, various tissues, feces and gut content, urine, saliva, cells / cell culture medium and more. Recommended amounts are for a single experiment — please ship 2–3× the recommended amount; keep sampling sites consistent across groups for tissue samples; ship on dry ice or cold chain. 
 

## Workflow

 WORKFLOW 1 Consultation Study goals / panel selection 2 Proposal & Quote Targets / timeline / agreement 3 Sample Intake Cold chain / pre-check / labeling 4 Experiment Acquisition / QC 5 Delivery Quantification + interpretation + raw data Deliverables: organic-acid source classification with abnormal-accumulation flags · absolute-quantification table for each metabolite (concentration + units) · group-wise T-test and fold-change analysis · PCA / PLS-DA modeling and hierarchical clustering · KEGG annotation and pathway enrichment · full analysis report and raw data. 
 

## Analysis Examples

 ANALYSIS EXAMPLES Example figures are generated from real project data; actual figures and analyses depend on the detection panel and study plan. T-test Bar Chart All metabolites sorted by ascending p-value; grouped bars show group means ± SD with p-values annotated beside the bars. Hierarchical Clustering Heatmap Z-score normalized abundance patterns of all metabolites; rows ordered by hierarchical clustering — red for high, blue for low abundance. Disease Association Bar Chart Known metabolite–disease associations mined from HMDB and other databases, ranked by the number of associated metabolites. Metabolite Abundance Analysis Faceted boxplots of significantly different metabolites between groups; intergroup comparison by Welch's t-test. Bar Chart Analysis Per-sample bar charts of differential metabolites, visualizing group differences and individual dispersion. 
 

## References

 REFERENCES [1] RATHOD R, GAJERA B, NAZIR K, et al. Simultaneous Measurement of Tricarboxylic Acid Cycle Intermediates in Different Biological Matrices Using Liquid Chromatography-Tandem Mass Spectrometry[J]. Metabolites, 2020, 10(3): 103. [2] HAGEN T, KORSON M S, SAKAMOTO M, et al. A GC/MS/MS screening method for multiple organic acidemias from urine specimens[J]. Clinica Chimica Acta, 1999, 283(1-2): 77-88. 
 

## Applications

 APPLICATIONS 
 TCA-cycle intermediate-metabolism research Gut-microbiota metabolism assessment Inherited organic-acidemia research Mitochondrial energy-metabolism analysis Metabolic-syndrome research 
 

## FAQ

 FAQ 
 How long does a Organic Acids Panel project take? Mature targeted panels typically take 1-3 weeks; untargeted projects take 2-4 weeks (counted from sample receipt and QC approval). The exact timeline is confirmed in writing before project start, and progress is trackable on the OmicsHub cloud platform. What if my sample amount is below the recommendation? Please do not dilute your samples. Low-input samples can often be accommodated by adjusting the preparation workflow — tell us the actual amount and our technical team will assess feasibility and note adjustments in the study plan. Can I add targets to an existing panel? Yes. Mature panels support on-demand additions; novel analytes outside the list can be implemented through custom method development (requires standards and extra validation time) — see our Custom Targeted Metabolomics service. What samples do you need for Organic Acids Panel? Serum/plasma ≥100 μL (fasting, no haemolysis), tissue ≥50 mg (snap-frozen), cells ≥1×10⁶ (medium washed off), urine ≥200 μL. Keep fasting time consistent, aliquot into single-use volumes and avoid freeze–thaw. Full guidance: Technical Resources → Sample Guide . 
 
 

## Related Services

 RELATED SERVICES 
 

### Glucose Metabolism Panel

Glucose Metabolism Panel

 

### Bile Acids Panel

Bile Acids Panel

 

### SCFA & MCFA Panel

SCFA & MCFA Panel

 
 
 

Delivery timing: sample shipping, customs declaration and similar steps may extend turnaround; actual project timelines prevail.

 
 
 
 

## Request a Quote or Study Design

Tell us about your project — we reply within one business day (free assessment)

 
 
 
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## Start Your Multi-omics Project

 

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