--- title: "Environmental Exposomics" lang: en url: https://www.gereallife.com/en/services/exposomics.html canonical: https://www.gereallife.com/en/services/exposomics.html entity: Shanghai Gereallife Biotech Co., Ltd updated: 2026-11-02 --- EXPOSOMICS # Environmental Exposomics Exposomics — Quantitative Profiling of Chemical Exposure A targeted quantification strategy to assess body burden and biological response to exogenous chemicals — pesticides, pharmaceuticals, industrial/environmental pollutants and lifestyle exposants. Absolute quantification against a 639-compound standards library on AB Sciex QTRAP 6500+ / 7500+ dual platforms, with limits of detection down to 0.002 ng/mL. Custom analyses including exposure–disease association, mixture joint effects and population stratification are supported, with full QC evaluation and statistics delivered with the report. 639 Target Compounds Quantified TARGET COMPOUNDS 6 Target Categories TARGET CLASSES 0.002 ng/mL Limit of Detection LIMIT OF DETECTION ## Technical Specifications TECHNICAL SPECIFICATIONS | Item | Details | | --- | --- | | Platform | AB Sciex QTRAP 6500+ / 7500+ dual platforms | | Quantification | Absolute quantification against a 639-compound standards library; LOD down to 0.002 ng/mL | | QC | Total ion chromatograms (TIC); RSD distribution in QCs and QC-sample correlations (generally > 0.99); internal standards and calibration curves applied throughout | | Custom Analyses | Multivariate association of exposure levels with region / age / BMI / clinical indicators; intergroup comparison and population stratification | | Mixture Joint Effects | WQS (weighted quantile sum regression) · BKMR (Bayesian kernel machine regression) · q-gcomp (quantile g-computation) | ## Analysis Workflow ANALYSIS WORKFLOW 1 Data Preprocessing Curation · comparison plan 2 Quality Control TIC · RSD · QC correlation 3 Detection Statistics Category statistics · clustering 4 Multivariate Stats PCA / OPLS-DA modeling 5 Differential Screening Volcano · Z-score 6 Distribution Analysis Cluster heatmap · violin plots 7 Custom Association Age / BMI / clinical indicators 8 Mixture Joint Effects WQS / BKMR regression models Analysis deliverables: full QC evaluation and statistical analyses delivered with the report, including the master quantification table, group-comparison plan, differential exposure list, association and joint-effect result tables, and all raw figure files. ## Target List — 6 Categories, 639 Compounds TARGET PANEL 2026 | Category | Coverage | Representative Compounds | | --- | --- | --- | | Pesticides | 353 | Chlorpyrifos, imidacloprid, atrazine, fipronil, spinosad A, etc.; 71 subcategories including 50 organophosphate insecticides, 28 triazole fungicides and 23 triazine herbicides | | Human Pharmaceuticals | 110 | Ibuprofen, sildenafil, nifedipine, carbamazepine, oseltamivir, etc.; 21 subcategories including 14 β2-agonists, 12 hypoglycemics and 12 antihistamines | | Industrial / Environmental Pollutants | 97 | PFOA, PFOS, bisphenol A, rhodamine B, etc.; 7 subcategories including 23 phthalates, 22 perfluorinated compounds and 21 phenolic pollutants | | Human / Veterinary Drugs | 35 | Azithromycin, sulfamethoxazole, progesterone, albendazole, ractopamine, etc.; 9 subcategories including 6 sex hormones, 6 NSAIDs and 6 antibiotics | | Veterinary Drugs | 24 | Fenbendazole, florfenicol, flumequine, nicarbazin, chloramphenicol, etc.; 10 subcategories including 7 anthelmintics, 4 quinolones and 3 anticoccidials | | Lifestyle Exposants | 20 | Nicotine, DEET, sucralose, triclocarban, 2-ethylhexyl salicylate, etc.; 4 subcategories including 13 cosmetics and 5 food additives | ## Bioinformatics Analyses BIOINFORMATIC MODULES | Module | Core Methods & Key Outputs | | --- | --- | | Data Preprocessing | Project data curation and exposure quantification matrix construction; group-comparison plan (single-group baseline / two-group comparison / multi-group stratification) — master quantification table | | Quality Control | Total ion chromatograms (TIC); RSD distribution and QC-sample correlations (generally > 0.99); internal standards and calibration curves throughout — TIC plots, RSD distribution plots | | Detection Statistics | Detection counts and rates by compound category; exposure clustering and concentration distribution — detection statistics tables, cluster plots, violin plots | | Multivariate Stats | PCA for group separation and outlier inspection; OPLS-DA discriminant modeling with 200 permutation tests — score plots, permutation-test plots | | Differential Exposure Screening | Fold change combined with p/q values to screen up- and down-regulated exposures — volcano plots, Z-score plots, differential exposure lists | | Differential Exposure Analysis | Hierarchical clustering, boxplots, lollipop charts and Spearman correlation analysis — cluster heatmaps, boxplots, lollipop charts | | Custom Association Analysis | Multivariate association of exposure with region / age / BMI / clinical indicators; population stratification — stratified violin plots, forest plots | | Mixture Joint Effects | WQS regression; BKMR; quantile g-computation — WQS weight plots, BKMR figure sets | ## Example Results SELECTED FIGURES FROM ACTUAL REPORTS Total Ion Chromatogram (TIC) Single-sample total ion chromatogram for assessing chromatographic separation and instrument response. QC Sample RSD Distribution RSD distribution and cumulative percentage of targets in QCs — 79.5% of compounds show RSD < 15%, indicating good reproducibility. QC Sample Correlation Pairs Plot Pairwise Pearson correlations among QC samples generally exceed 0.99, demonstrating system stability and data reliability. Differential Exposure Volcano Plot Dual thresholds of log2(FC) and −log10(P) mark up/down-regulated exposures; bubble size maps VIP values. Intergroup Hierarchical Clustering Heatmap Top differential exposures clustered by sample, visualizing exposure-profile differences between groups. Intergroup Z-score Plot Z-score distribution of differential exposures across samples, comparing direction and magnitude of exposure shifts between groups. Exposure–Disease Association Forest Plot Odds ratios (log scale) and significance of top-30 exposure–disease associations, adjusted for age, region and BMI. WQS Joint-Exposure Weight Analysis Weighted quantile sum (WQS) regression estimates each exposure's contribution weight to the mixture effect and overall risk. ## Applications APPLICATIONS Environmental Pollutant Exposure Assessment Occupational Health Monitoring Food Safety Risk-Compound Screening Exposure–Disease Association Environmental Epidemiology Cohorts ## FAQ FAQ How long does a Environmental Exposomics project take? Mature targeted panels typically take 1-3 weeks; untargeted projects take 2-4 weeks (counted from sample receipt and QC approval). The exact timeline is confirmed in writing before project start, and progress is trackable on the OmicsHub cloud platform. What if my sample amount is below the recommendation? Please do not dilute your samples. Low-input samples can often be accommodated by adjusting the preparation workflow — tell us the actual amount and our technical team will assess feasibility and note adjustments in the study plan. Can I add targets to an existing panel? Yes. Mature panels support on-demand additions; novel analytes outside the list can be implemented through custom method development (requires standards and extra validation time) — see our Custom Targeted Metabolomics service. What samples do you need for Environmental Exposomics? Serum/plasma ≥100 μL (fasting, no haemolysis), tissue ≥50 mg (snap-frozen), cells ≥1×10⁶ (medium washed off), urine ≥200 μL. Keep fasting time consistent, aliquot into single-use volumes and avoid freeze–thaw. Full guidance: Technical Resources → Sample Guide . ## Related Services RELATED SERVICES ### Metabolic Flux & Isotope Tracing Metabolic Flux & Isotope Tracing ### Targeted Metabolomics Targeted Metabolomics ### Untargeted Metabolomics Untargeted Metabolomics Delivery timing: sample shipping, customs declaration and similar steps may extend turnaround; actual project timelines prevail. ## Request a Quote or Study Design Tell us about your project — we reply within one business day (free assessment) Name Organization Phone or WeChat Service of interest Sample type, number of samples and aims (optional) Submit Used only for this enquiry; never shared. ## Start Your Multi-omics Project Free study design · Interactive execution · In-depth data interpretation HOTLINE 400-660-8826 EMAIL market@gereallife.com Official Channels OFFICIAL CHANNELS Official Account WECHAT OFFICIAL ACCOUNT WeChat Service CUSTOMER SERVICE Xiaohongshu XIAOHONGSHU Call us： 400-660-8826 Scan to chat on WeChat